Throughout her years as an actress, Sher has played a number of roles in television series, but many of these were short lived, as the series were either canceled or her character was eliminated. It was not until she landed a role as Sue Heck on the television seriesThe Middlethat she gained a starring and more permanent role. Since 2009, Sher has starred in the ABC comedy seriesThe Middleas Sue Heck, a quirky but optimistic teenager. In 2013, she won theCritics' Choice Television Award for Best Comedy Supporting Actressfor her role inThe Middle.In 2006, she played the role of Gretchen, a middle school love interest for one of the main characters, Alexander Gould, in the comedy-drama seriesWeeds. Later that same year, she landed the regular role of Carrie Fenton onSons & Daughters, which was canceled 11 episodes into its first season.In 2007, Sher played a student attending Harbor High in the final season of the seriesThe O.C..She also appeared in the 2001 short film "Stuck" and ads forCapital OneandFruity Pebbles.
2001年9月,首次参演美国电影短片《Stuck》饰演Caterpillar Girl。
2006年3月,首次参演美国电视剧《Sons & Daughters》饰演Carrie Fenton。
2006年8月,参演美国电视剧《单身毒妈第二季》饰演Gretchen。
2009年9月,参演美国家庭情景喜剧《左右不逢源》饰演休·赫克。
2013年,自编自导短片喜剧《The Suitcase》并担任制片人。
2015年,担任喜剧片《ImagiGARY》并担任执行制片人。
2016年,参加电视喜剧节目《Sing It!》。